Hence, we conducted a quantitative systematic review along with a comprehensive meta-analysis investigation among a large sample of T2DM patients to estimate the predicting value and prognostics accuracy of LDL and SBP in T2DM patients with and without peripheral neuropathy. Despite numerous experimental studies, the prognostic value of LDL and SBP for survival in T2DM patients with DPN is still controversial and inconclusive. Certainly, understanding the role of LDL and SBP in pathogenesis and collision risk of diabetic neuropathy could help to develop effective treatments and road safety regulations for type 2 diabetic neuropathy.
COMPREHENSIVE META ANALYSIS 2.2.064 DRIVERS
It is interesting to note that collision risk in DPN drivers changed over time in old age of T2DM patients.
COMPREHENSIVE META ANALYSIS 2.2.064 SERIES
Many time series meta-regression analysis tried to determine whether LDL and SBP are associated with an increased collision risk of DPN. Although, intervention treatment strategies have thus far not revealed that a specific pharmacologic approach can prevent T2DM neuropathy. Clinically, the difference values of LDL and SBP can be used for early diagnosis and differentiation of T2DM patients with and without peripheral neuropathy. It has been widely reported that different serum level of LDL is related to poor survival and prognosis of polyneuropathy in diabetic patients. T2DM patients suffering from peripheral neuropathy have different low-density lipoprotein (LDL) and systolic blood pressure (SBP) profiles that potentially influence the occurrence of DPN. Accumulated evidence suggests that improvement in glycemic control and blood pressure control have all helped to reduce the incidence and progression of diabetic neuropathy. Also, compositional abnormalities in lipoproteins play an important role in the progression of atherosclerosis in T2DM with nephropathy. Many studies have confirmed that DPN progression is strongly associated with cardiovascular and metabolic risk factors, such as obesity, hypertension, hyperfibrinogenemia, hypercholesterolemia and dyslipidemia. The typical DPN is a distal symmetric polyneuropathy that is characterized by the neuropathy experience symptoms such as hyperalgesia, paresthesia, amputation, burning pain, stabbing sensations, hyperesthesia, and deep aching pain. Over the last 10 years, the overall annualized incidence rates of DPN have been rapidly increased from 9.4 to 61.8% in a population of diabetic neuropathies. Our finding supports the LDL and SBP status could be associated with increased risk of peripheral neuropathy in T2DM patients.ĭiabetic peripheral neuropathy (DPN) is the major debilitating chronic complication of type-2 diabetes mellitus (T2DM), with an estimated lifetime incidence of about 47% of patients with T2DM and 21% of pre-diabetes. Furthermore, the results of the case-control study design model are more precise to show the accuracy of SBP in Asian T2DM patients. Old age European T2DM patients have significantly high risk for diabetes drivers. European T2DM patients have higher serum level of LDL in compare with the European DPN patients (SMD = 0.16, 95% CI: − 0.06 - 0.38 P < 0.001). There was a significant association between LDL and SBP with poor prognosis of DPN in those included studies (I 2 = 88.1% and I 2 = 84.9%, respectively, Both P < 0.001). We performed random effects meta-regression analyses to investigate factors associated with an increased collision risk of DPN. The standardized mean difference (SMD) with 95% CI of LDL and SBP level were pooled to assess the correlation between LDL and SBP level with DPN. The quality of the included studies was assessed by the QUADAS-2 tool. MethodsĪ systematic search was conducted for eligible publications which explored the LDL and SBP level in T2DM patients with and without peripheral neuropathy. We also tried to determine whether LDL and SBP are associated with an increased collision risk of DPN. This systematic review aimed to estimate the predicting value of low-density lipoprotein (LDL) and systolic blood pressure (SBP) level in type-2 diabetes mellitus (T2DM) patients with and without peripheral neuropathy. Compositional abnormalities in lipoproteins and cardiovascular risk factors play an important role in the progression of diabetic peripheral neuropathy (DPN).
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